Decorin is specifically solubilized by heparin from the extracellular matrix of rat skeletal muscles

FEBS Letters

Brandan, Enrique¹  Melo, Francisco¹ 

[1] Molecular Neurobiology Unit, Department of Cell and Molecular Biology, Faculty of Biologycal Sciences, Catholic University of Chile, P.O. BOX 114-D, Santiago, Chile

关键词: Decorin;    Proteoglycan;    Glycosaminoglycan;    Neuromuscular junction: Extracellular matrix;   

DOI  :  10.1016/0014-5793(93)80556-A

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have previously communicated that heparin co-solubilizes the asymmetric form of acetylcholinesterase (AChE) and a dermatan sulfate proteoglycan from the extracellular matrix (ECM) of rat skeletal muscles. In this report we unequivocally demonstrate by biochemical and immunological analyses that the proteoglycan that is solubilized by heparin from rat skeletal muscle ECM corresponds to decorin. These results support the concept for the role of decorin in the ECM organization.

【 授权许可】

Unknown