Genes of variola and vaccinia viruses necessary to overcome the host protective mechanisms

FEBS Letters

Sandakhchiev, Lev S.¹  Blinov, Vladimir M.¹  Shchelkunov, Sergei N.¹ 

[1] Institute of Molecular Biology NPO ‘Vector’, Koltsovo, 633159 Novosibirsk region, Russian Federation

关键词: Variola virus;    Complement-binding protein;    Serine protease inhibitor;    Lymphokine receptor;    VAR;    variola virus;    VAC;    vaccinia virus;    CAM;    chorioallantoic membrane;    TNF;    tumor necrosis factor;    IL;    interleukin-1;    INF;    interferon;   

DOI  :  10.1016/0014-5793(93)80041-R

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Analysis of variola virus nucleotide sequence revealed proteins belonging to several families which provide the virus with the possibility of overcoming the barriers of specific and non-specific host defence against viral infection. The complement-binding proteins, lymphokine-binding proteins, and serine protease inhibitors can be assigned to this type, as can the proteins providing the orthopoxviruses with resistance to interferon. The revealed differences between the genes (proteins) of variola and vaccinia viruses under study are discussed.

【 授权许可】

Unknown