Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells

FEBS Letters

McGill, Jeffrey¹  Jhiang, Sissy M.¹  Mazzaferri, Ernest L.¹  Smanik, Patricia¹  Fithian, Linda¹  Tong, Qiang¹ 

[1] Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA

关键词: Human;    Thyroid;    Taurine;    Transporter;    cDNA;    Sequence;   

DOI  :  10.1016/0014-5793(93)80008-I

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A cDNA clone encoding a taurine transporter, designated HTAU, has been isolated from human thyroid. It contains an open reading frame encoding a protein of 619 amino acids with a calculated molecular weight of 69,675 Da. The predicted amino acid sequence of HTAU is highly homologous to those of dog kidney and rat brain. The HTAU mRNA was detectable in various human tissues examined. Transient expression of HTAU in COS-7 cells conferred a higher taurine uptake. The taurine uptake in FRTL-5 cells appears to be regulated by thyrotropin through cAMP. Finally, a higher taurine uptake may be associated with a higher proliferation rate in some cultured cell lines.

【 授权许可】

Unknown