Binuclear centre structure of terminal protonmotive oxidases

FEBS Letters

Brown, Simon¹  Mitchell, Roy¹  Rich, Peter R.¹  Moody, A.John¹ 

[1] Glynn Research Institute, Bodmin, Cornwall, PL30 4AU. UK

关键词: Cytochrome c oxidase;    Cytochrome bo;    structure;    Sequence conservation;   

DOI  :  10.1016/0014-5793(93)81296-C

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The recent proliferation of data obtained from mutant forms of cytochrome oxidase and analogous enzymes has necessitated a re-examination of existing structural models. A new model is proposed, consistent with these data, which brings several protonatable residues (Y244, D298, D300, T309, T316, K319, T326) into the vicinity of the binuclear centre, suggestive of a proton-transferring function. In addition, we also consider those residues which may participate in electron transport between Cu_A and haem a. We suggest several potential lines of investigation.

【 授权许可】

Unknown