Localization of Kex2‐like processing endoproteases, furin and PC4, within mouse testis by in situ hybridization

FEBS Letters

Yamagishi, Toshiyuki¹  Murakami, Kazuo¹  Torii, Seiji¹  Nakayama, Kazuhisa² 

[1] Institute of Applied Biochemistry University of Tsukuba, Tsukuba, Ibaraki 305, Japan;Institute of Biological Sciences University of Tsukuba, Tsukuba, Ibaraki 305, Japan

关键词: Proenkephalin;    Prohormone processing;    Spermatogenic cell;    Yeast Kex2 protease;   

DOI  :  10.1016/0014-5793(93)81726-G

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

By in situ hybridization analysis, we show here the localization of furin and PC4, which are both members of a growing family of endoproteases structurally related to the yeast precursor processing protease Kex2, within mouse testis. Furin transcript was detected in both germ and somatic cells, while PC4 transcript was found only in round spermatids. Proenkephalin transcript was also localized in round spermatids. These observations suggest that, within testis, PC4 is involved in processing of peptide precursors such as proenkephalin and may play a role in regulation of sperm maturation. while furin may serve as a more general processing endoprotease.

【 授权许可】

Unknown