The rat delta‐1 and delta‐2 subunits extend the excitatory amino acid receptor family

FEBS Letters

Köhr, G.¹  Lomeli, H.¹  Herb, A.¹  Laurie, D.J.¹  Seeburg, P.H.¹  Sprengel, R.¹  Wisden, W.¹ 

[1] Laboratory of Molecular Neuroscience, Center for Molecular Biology (ZMBH), Heidelberg University, INF282, D-6900 Heidelberg, Germany

关键词: Glutamate receptor;    Rat brain;    Purkinje cell;   

DOI  :  10.1016/0014-5793(93)81186-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have characterized a second member (delta-2) of a new class of subunits for the ligand-gated excitatory amino acid receptor superfamily. The sequence of delta-2 exhibits an average identity of 25% and 18.5% to the non-NMDA and NMDA receptor subunits, respectively. The rat delta-2 gene is expressed predominantly in Purkinje cells of the cerebellum whereas only low levels of delta-1 transcripts are found in the adult brain. However, delta-1 gene expression undergoes a pronounced developmental peak, with particularly high mRNA levels in the caudate putamen of late embryonic/early postnatal stages.

【 授权许可】

Unknown