Role of ADP‐ribosylation in endothelial signal transduction and prostacyclin production

FEBS Letters

Thorgeirsson, Gudmundur¹  Bödvarsdóttir, Thora¹  Kjeld, Matthías²  Halldórsson, Haraldur¹ 

[1] Department of Pharmacology, University of Iceland, Landspitalinn, National University Hospital, Reykjavlk, Iceland;Department of Clinical Chemistry, University of Iceland, Landspitalinn, National University Hospital, Reykjavlk, Iceland

关键词: Endothelium;    Mono ADP-ribosylation;    Signal transduction;    Prostacyclin;    LAME;    l-arginine methyl ester;    MIBG;    meta-iodobenzylguanidine;    MIBA;    meta-iodobenzylamine;    PGI2;    prostacyclin;   

DOI  :  10.1016/0014-5793(92)81497-A

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

ADP-ribosylation of proteins by the enzymatic transfer of ADP-ribose from NAD has been implicated in a number of biological processes. We report that inhibitors of ADP-ribosylation, most notably the novel inhibitor of arginine specific cellular mono(ADP-ribosyl) transferase, meta-iodobenzylguanidine (MIBG) as well as nicotinamide, l-arginine methyl ester (LAME) and guanyltyramine, inhibit histamine-induced endothelial production of inositol phosphates, release of arachidonic acid and production of prostacyclin (PGI₂). Those same responses were unaffected by MIBG when triggered by thrombin or leukotriene C₄. These findings suggest that ADP-ribosylation serves a role in histamine-induced production of prostacyclin and imply differences in transduction pathways employed by the different agonists.

【 授权许可】

Unknown