Specific cleavage of DNA at CG sites by Co(III) and Ni(II) desferal complexes

FEBS Letters

Ganesh, K.Nagappa¹  Joshi, Rajendra R.¹ 

[1]Bio-organic Chemistry Unit, Division of Organic Chemistry, National Chemical Laboratory, Pune 411008, India

关键词: Desferal;    DNA cleavage;    Sequence specificity;    DFO;    desferrioxamine;    ME;    mercaptoethanol;    Pip;    piperidine;    DTT;    dithiothreitol;    OP;    phenanthroline;    BLM;    bleomycin;    EDTA;    ethylenediamine tetraacetic acid;    PAGE;    polyacrylamide gel electrophoresis;    Cu(II);    Ni(II) and Co(III) desferal complexes are denoted as Cu-DFO;    Ni-DFO and Co-DFO;    respectively;   

DOI  :  10.1016/0014-5793(92)81215-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It is demonstrated that Co(III) and Ni(II) complexes of desferal, a siderophore chelating drug, show specificity for cleavage of DNA at CG sites, while the corresponding Cu(II) complex cleaves DNA sequences at both CG and AT sites.

【 授权许可】

Unknown