Dopaminergic stimulation up‐regulates the in vivo expression of brain‐derived neurotrophic factor (BDNF) in the striatum

FEBS Letters

Kanazawa, Ichiro¹  Murata, Miho¹  Kamei, Masaki¹  Watanabe, Masahiko¹  Okazawa, Hitoshi¹ 

[1] Department of Neurology, Faculty of Medicince, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan

关键词: Brain-derived neurotrophic factor;    Dopamine;    Transcription;    Striatum;   

DOI  :  10.1016/0014-5793(92)81430-T

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We investigated the effect of dopamine on the in vivo expression of brain-derived neurotrophic factor (BDNF) in the striatum of mouse. BDNF mRNA expression in the striation, which was Quantified with the reverse transcriptase polymerase chain reaction, was up-repulated from 2 h after oral administration of levodopa, a precursor of dopamine. The increase was sustained for 16 h. Co-administrstion of haloperidol partially inhibited dopamine-induced BDNF enhancement. These data suggest that dopaminergic stimulation directly promotes the expression of BDNF in the striatum in vivo.

【 授权许可】

Unknown