Relationship between primary structure and activity in exorphins and endogenous opioid peptides

FEBS Letters

Nyberg, Fred¹  Ya. Bakalkin, Georgy²  Demuth, Hans-Ulrich¹ 

[1] Department of Pharmacology, University of Uppsala, S-751 24 Uppsala, Sweden;Department of Drug Independence Research, Karolinska Institute, S-10401 Stockholm, Sweden

关键词: Opioid peptides;    Primary structure-activity relationship;   

DOI  :  10.1016/0014-5793(92)81135-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have found a correlation between the certain characteristics of primary structure and biologic activity in exorphins and endogenous opioid peptide family. The characteristics of primary structure are the content of certain segment pairs as well as the density of their arrangement in a peptide. These segment pairs represent basic elements of the regulatory peptide primary structure pattern, which was found recently [Dokl. Akad. Nauk USSR 289 (1986) 721–724; Int. J. Peptide Prot. Res. 38 (1991) 505–510].

【 授权许可】

Unknown