Parental imprinting of the human H19 gene

FEBS Letters

Goshen, Ran¹  Rachmilewitz, Jacob³  Hochberg, Abraham³  Schneider, Tamar³  Ariel, Ilana²  de Groot, Nathan³ 

[1] Department of OB/Gyn, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel;Department of Pathology, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel;Department of Biological Chemistry, The Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel

关键词: H19;    IGF-II;    Human genomic imprinting;    Hydatidiform mole;    Androgenetic tissue;   

DOI  :  10.1016/0014-5793(92)80731-U

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It has only recently become clear that genetic imprinting plays an important role in human embryogenesis and in processes leading to the development of pediatric cancers and other human diseases. Using a unique human tissue, the androgenetic complete hydatidiform mole, we established that the maternally inherited allele of the imprinted H19 gene is expressed. Our results also show that the paternal allele of the human IGF-II gene, a gene suspected to be parentally imprinted in humans, is expressed.

【 授权许可】

Unknown