Flow‐induced prostacyclin production is mediated by a pertussis toxin‐sensitive G protein

FEBS Letters

Berthiaume, Francois¹  Frangos, John A.¹ 

[1] Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA

关键词: Prostacyclin;    G protein;    Pertussis toxin;    Shear stress;    Histamine;    Endothelial cell;   

DOI  :  10.1016/0014-5793(92)81292-T

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Fluid flow and several other agonists induce prostacyclin (PGI₂) production in endothelial cells, G proteins mediate the response of a large number of hormones such as histamine, but the transduction pathway of the flow signal is unclear. We found that GDPβS and pertussis toxin inhibited flow-induced prostacyclin production in human umbilical vein endothelial cells. In addition, flow potentiated the histamine-induced production of PGI₂. This suggests that flow stimulates prostacyclin production via a pertussis toxin-sensitive G protein and modulates the stimulus-response coupling of other agonists.

【 授权许可】

Unknown