Monitor peptide gene expression is increased by exogenous CCK in the rat pancreas and in a rat pancreatic acinar cell line (AR4‐2J)

FEBS Letters

Tsuzuki, Satoshi¹  Fushiki, Tohru¹  Kondo, Atsuko¹  Sugimoto, Etsuro¹ 

[1] Laboratory of Nutritional Chemistry, Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606, Japan

关键词: Monitor peptide;    mRNA level;    Cholecystokinin (CCK);    CCK antagonist;    Pancreas;    AR4-2J;    CCK;    cholecystokinin;   

DOI  :  10.1016/0014-5793(92)80719-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Monitor peptide (CCK-releasing peptide) mRNA increased on the administration of CCK in rat pancreas and the AR4-2J pancreatic cell line. Subcutaneous injection of CCK into rats at 8 h intervals increased the level of monitor peptide mRNA in the pancreas. Concomitant injection of CCK antagonist CR-1409 strongly decreased it. The monitor peptide mRNA was also increased by CCK in AR4-2J cells and was decreased by the antagonist. These findings suggest that the plasma CCK induced by prolonged intake of a high protein diet may be responsible for the adaptive increase in the monitor peptide as well as exocrine proteases in the pancreas.

【 授权许可】

Unknown