A novel class of nucleolar RNAs from Tetrahymena

FEBS Letters

Ørum, Henrik¹  Engberg, Jan¹  Nielsen, Henrik² 

[1] Department of Biological Sciences, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen, Denmark;Department of Biochemistry B, Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark

关键词: Nucleolar RNA;    RNA sequencing;    Tetrahymena thermophila;    snoRNA;    small nucleolar RNA;    snRNA;    small nuclear RNA;    rRNA;    ribosomal RNA;    tRNA;    transfer RNA;    rDNA;    ribosomal RNA genes;    m3G;    trimethyl guanosine;   

DOI  :  10.1016/0014-5793(92)80708-O

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We describe a family of at least four nucleolar RNAs (snoRNAs) from the ciliate, Tetrahymena. The snoRNAs are 120–140 nucleotides long, moderately AU-rich and contain no modified nucleotides. Their 5′ ends are blocked by a cap of unknown nature. The snoRNAs can be folded into similar secondary structures consisting of two hairpins separated by a single-stranded AU-rich spacer. The sequences and secondary structures show no extensive sequence or secondary structure resemblance to any other small RNAs in the public databases.

【 授权许可】

Unknown