Isoproterenol‐induced Mg2+ uptake in liver

FEBS Letters

Günther, Theodor¹  Vormann, Jürgen¹  Höllriegl, Vera¹ 

[1] Institute of Molecular Biology and Biochemistry, Free University of Berlin, Arnimallee 22, D-W-1000 Berlin 33, Germany

关键词: Magnesium influx;    Isoproterenol;    cAMP;    Protein kinase C;    Rat liver;   

DOI  :  10.1016/0014-5793(92)80707-N

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Isoproterenol increased the Mg²⁺ content of hepatocytes after injection into rats or after addition to collagenase-dispersed hepatocytes. cAMP also the increased cellular Mg²⁺ content of isolated hepatocytes. This effect was prevented by staurosporine. Phorbol ester had no effect on the Mg²⁺ content of isolated hepatocytes, and after injection of isoproterenol into rats, protein kinase C of liver was not affected. It was concluded that isoproterenol induced long-term Mg²⁺ influx via the activation of protein kinase A which can be inhibited by staurosporine.

【 授权许可】

Unknown