Pre‐translational regulation by glucocorticoid of fatty acid and phosphatidylcholine synthesis in type II cells from fetal rat lung

FEBS Letters

Batenburg, J.J.¹  Elfring, R.H.¹ 

[1] Laboratory of Veterinary Biochemistry, Utrecht University, PO Box 80176, 3508 TD Utrecht, The Netherlands

关键词: Lung surfactant;    Fatty acid synthase;    Acetyl-CoA carboxylase;    ATP citrate lyase;    CTP:phosphocholine cytidylyltransferase;    Glucocorticoid;   

DOI  :  10.1016/0014-5793(92)80759-A

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Exposure to fibroblast-conditioned cortisol-containing medium increased fatty acid synthase activity and fatty acid synthase, acetyl-CoA carboxylase and ATP citrate lyase mRNA abundance in fetal type II alveolar epithelial cells. Both fibroblast conditioning and cortisol in the medium were required for maximal effect on the mRNA levels, indicating involvement of mesenchymal—epithelial interaction in the cortisol effects. The observed effects provide evidence for an earlier hypothesis that increased activity of CTP:phosphocholine cytidylyltransferase in lung tissue caused by glucocorticoid is due to increased fatty acid synthesis. However, evidence suggesting pre-translational regulation of the enzyme by glucocorticoid was also found.

【 授权许可】

Unknown