Apoptosis Biochemical events and relevance to cancer chemotherapy

FEBS Letters

D'Incalci, Maurizio¹  Sen, Soumitra¹ 

[1] Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via Eritrea 62, 1-20157 Milano, Italy

关键词: Anticancer agent;    bcl-2;    Calcium;    Cell cycle phase;    p34cilc2;    p53;    Programmed cell death;    Regulation;    Sulphated glycoprotein;   

DOI  :  10.1016/0014-5793(92)80914-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two distinct pathways for cell death exist. Compared to necrotic death, physiological or apoptotic cell death is an active suicidal process that consists of a cascade of well-regulated synthetic events. Participation of specific genes in apoptosis, and its possible molecular regulation, are considered in order to investigate the mechanism of cell death induced by some cancer chemotherapeutic agents.

【 授权许可】

Unknown