FEBS Letters | |
Is thioredoxin the physiological vitamin K epoxide reducing agent? | |
Preusch, Peter C.1  | |
[1] Deparment of Chemistry, The University of Akron, Akron, OH 44325, USA | |
关键词: Vitamin K epoxide reductase; Thioredoxin; Thioredoxin reductase; Salicylate inhibition; | |
DOI : 10.1016/0014-5793(92)80681-6 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
E. coli thioredoxin plus thioredoxin reductase have previously been shown to replace dithiothreitol as the electron donor for mammalian liver microsomal vitamin K epoxide reduction in vitro. Such activity is dependent on detergent disruption of the microsomal membrane integrity. A previously characterized salicylate-inhibitable pathway for electron transfer from endogenous cylosolic reducing agents to the microsomal epoxide reducing warfarin-inhibitable enzyme is not inhibited by known alternate substrates and inhibitors of the thioredoxin system nor by antibodies against thioredoxin.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020296497ZK.pdf | 368KB | download |