Is thioredoxin the physiological vitamin K epoxide reducing agent?

FEBS Letters

Preusch, Peter C.¹ 

[1] Deparment of Chemistry, The University of Akron, Akron, OH 44325, USA

关键词: Vitamin K epoxide reductase;    Thioredoxin;    Thioredoxin reductase;    Salicylate inhibition;   

DOI  :  10.1016/0014-5793(92)80681-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

E. coli thioredoxin plus thioredoxin reductase have previously been shown to replace dithiothreitol as the electron donor for mammalian liver microsomal vitamin K epoxide reduction in vitro. Such activity is dependent on detergent disruption of the microsomal membrane integrity. A previously characterized salicylate-inhibitable pathway for electron transfer from endogenous cylosolic reducing agents to the microsomal epoxide reducing warfarin-inhibitable enzyme is not inhibited by known alternate substrates and inhibitors of the thioredoxin system nor by antibodies against thioredoxin.

【 授权许可】

Unknown