Combinatorial RNA splicing alters the surface charge on the NMDA receptor

FEBS Letters

Treistman, Steven N.¹  Anantharam, Vellareddy¹  Kolchine, Vladimir V.¹  Wilson, Andrew¹  Bayley, Hagan²  Panchal, Rekha G.² 

[1] Department of Pharmacology, University of Massachusetts Medical Center, Worcester, MA 01655, USA;Worcester Foundation for Experimental Biology, Shrewsbury, MA 01545, USA

关键词: Receptor;    Channel;    Excitatory amino acid;    Glutamate;    RNA splicing;   

DOI  :  10.1016/0014-5793(92)80648-Z

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Transcripts encoding four NMDA receptor subunits, generated from the NMDAR1 gene by alternative RNA splicing, have been demonstrated in adult rat brain. RNA transcripts derived from cDNAs encoding each form direct the formation of functional NMDA receptors in Xenopus oocytes. The two amino acid cassettes of 21 and 37 amino acids found in the splice variants increase the positive extracellular surface charge on the subunits and may thereby modulate the functional properties of the receptor.

【 授权许可】

Unknown