Correlation between local cell membrane displacements and filterability of human red blood cells

FEBS Letters

Tuvia, Shmuel¹  Levin, Shlomo¹  Korenstein, Rafi¹ 

[1] Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, 69978 Tel-Aviv, Israel

关键词: Erythrocyte deformability;    Cell membrane fluctuation;    Erythrocyte filterability;    Osmosis;    Membrane curvature;    Microcirculation;   

DOI  :  10.1016/0014-5793(92)80583-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Local mechanical fluctuations of the cell membrane of human erythrocytes were shown to involve MgATP- and Mg²⁺-driven fast membrane displacements. We propose that these local bending deformations of the cell membrane are important for cell passage through capillaries. In order to verify this hypothesis, we examined cell membrane fluctuations and filterability of erythrocytes over a wide range of medium osmolalities (180–675 mosmol/kg H₂O). The results indicate the existence of a positive correlation between the amplitude of local cell membrane displacements and cell filterability. We suggest that the occurrence of metabolically driven membrane displacements on the side surface of the red blood cell diminishes its bending stiffness and enables it to fold more efficiently upon entrance into blood capillaries. Thus, local cell membrane displacements seem to play an important role in microcirculation.

【 授权许可】

Unknown