Multiple genes for Xenopus activin receptor expressed during early embryogenesis

FEBS Letters

Murakami, Kazuo¹  Ueno, Naoto¹  Oda, Satoshi¹  Nishimatsu, Shin-ichiro¹ 

[1] Institute of Applied Biochemistry, University of Tsukuba, Tsukuba, Ibaraki 305, Japan

关键词: Activin;    Transforming growth factor-β (TGF-β);    Receptor;    Serine/theorine kinase;    Xenopus laevis;   

DOI  :  10.1016/0014-5793(92)80482-V

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Four distinct cDNAs for activin receptor designated as XSTK2, 3, 8 and 9 have been cloned from a Xenopus laevis cDNA library. The protein structures deduced from the cDNAs have shown that they all have a putative extracellular ligand-binding domain, a single transmembrane domain and cytoplasmic Ser/Thr kinase domain, except that XSTK2 is extremely similar to the XSTK3 gene but lacks a carboxyl-terminal part of the kinase motif. Northern blot analysis showed that all transcripts are maternally inherited. The levels or transcript for XSTK2, 3 and 8 appeared to fluctuate during early development while those for XSTK9 maintain constant.

【 授权许可】

Unknown