FEBS Letters | |
A large domain common to sperm receptors (Zp2 and Zp3) and TGF‐β type III receptor | |
Sander, Chris1  Bork, Peer1  | |
[1] EMBL, Meyerhofstr, 1, 6900 Heidelberg, Germany | |
关键词: Homology; Mosaic protein; Sperm receptor: TGF-receptor; Uromodulin; TGFR3; transforming growth factor β type III receptor; Zp2 (Zp3); sperm receptor Zp2 (Zp3); GP2; major zymogen granule membrane protein; | |
DOI : 10.1016/0014-5793(92)80853-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
A new family of mosaic proteins is defined by sequence analysis. The family is characterized by a 260 residue domain common to proteins of apparently diverse function and tissue specificity; sperm receptors Zp2 and Zp3, betaglycan (also called TGF-β type III receptor), uromodulin, as well as the major zymogen granule membrane protein (GP-2). The location of the common domain is similar with respect to putative transmembrane regions. The results lead to the hypothesis that this type of domain has a common tertiary structure and that there is a functional similarity in the recognition mechanism of the sperm receptor system and the TGF-β receptor complex.
【 授权许可】
Unknown
【 预 览 】
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