A large domain common to sperm receptors (Zp2 and Zp3) and TGF‐β type III receptor

FEBS Letters

Sander, Chris¹  Bork, Peer¹ 

[1] EMBL, Meyerhofstr, 1, 6900 Heidelberg, Germany

关键词: Homology;    Mosaic protein;    Sperm receptor: TGF-receptor;    Uromodulin;    TGFR3;    transforming growth factor β type III receptor;    Zp2 (Zp3);    sperm receptor Zp2 (Zp3);    GP2;    major zymogen granule membrane protein;   

DOI  :  10.1016/0014-5793(92)80853-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A new family of mosaic proteins is defined by sequence analysis. The family is characterized by a 260 residue domain common to proteins of apparently diverse function and tissue specificity; sperm receptors Zp2 and Zp3, betaglycan (also called TGF-β type III receptor), uromodulin, as well as the major zymogen granule membrane protein (GP-2). The location of the common domain is similar with respect to putative transmembrane regions. The results lead to the hypothesis that this type of domain has a common tertiary structure and that there is a functional similarity in the recognition mechanism of the sperm receptor system and the TGF-β receptor complex.

【 授权许可】

Unknown