Genetic alterations by human papillomaviruses in oncogenesis

FEBS Letters

Lazo, Pedro A.¹  Feduchi, Elena¹  Gallego, Marta I.¹  Ballester, Sara¹ 

[1] Unidad de Genética Molecular, Centro Nacional de Biología Celular y Retrovirus, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain

关键词: Papillomavirus;    Oncogen;    Tumor phenotype;   

DOI  :  10.1016/0014-5793(92)80175-G

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The integration sites in the cellular genome of human papillomavirus are located in chromosomal regions always associated with oncogenes or other known tumor phenotypes. Two regions, 8q24 and 12q13, are common to several cases of cervical carcinoma and can have integrated more than one type of papillomavirus DNA. These two chromosomal regions contain several genes implicated in oncogenesis. These observations strongly imply that viral integration sites of DNA tumor viruses can be used as the access point to chromosomal regions where genes implicated in the tumor phenotype are located, a situation similar to that of non-transforming retroviruses.

【 授权许可】

Unknown