Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL60 leukemic cells

FEBS Letters

Najid, A.¹  Cook, J.¹  Chable-Rabinovitch, H.¹  Delage, C.²  Simon, A.²  Rigaud, M.¹  Chulia, A.J.³ 

[1] CJF INSERM 88-03, Faculté de Médecine, Faculté de Pharmacie, Université de 'Limoges, 2 rue Dr. Marcland, 87025 Limoges, France;Laboratoire de Chimie Physique, Faculté de Pharmacie, Université de 'Limoges, 2 rue Dr. Marcland, 87025 Limoges, France;Laboratoire de Pharmacognosie, Faculté de Phamacie, Université de 'Limoges, 2 rue Dr. Marcland, 87025 Limoges, France

关键词: Lipoxygenase;    Arachidonic acid;    Cyclooxygenase;    Ursolic acid;    Calluna vulgaris;   

DOI  :  10.1016/0014-5793(92)80117-Y

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A new property of ursolic acid, lipoxygenase and cyclooxygenase inhibition, has been described in an acetone-extract of heather flowers (Calluna vulgaris) wllich could help explain the anti-inflammatory characteristics of this plant. In mouse peritoneal macrophages, human platelets and differentiated HL60 leukemic cells, ursolic acid, at 1 μM, blocks arachidonate metabolism.

【 授权许可】

Unknown