The rate of catabolism of dATP to deoxyadenosine during the growth of different cell lines in vitro

FEBS Letters

Marcussen, Mads¹  Klenow, Hans¹ 

[1] Biokemisk Institut B, Panum Instituttet, The University of Copenhagen, Copenhagen, Denmark

关键词: dATP;    Catabolism;    Deoxyadenosine;    Cultured cell;   

DOI  :  10.1016/0014-5793(92)80233-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A method has been developed for the determination of the rate of formation or deoxyadenosine from dATP in cultured cell lines. The lowest rate was found in the T-cell-derived Molt cell line while it was about 70-fold higher in Balb c/3T3 mouse fibroblasts. In the B-cell-derived Raji cells and in the murine sarcoma cell line SEWA it had intermediary values. It is concluded that in some cell types like the 3T3-cells the catabolism of dATP to deoxyadenosine may have a significant regulatory eftect on the cellular content of dATP.

【 授权许可】

Unknown