期刊论文详细信息
FEBS Letters | |
Isolation and characterization of a bradykinin‐potentiating peptide from a bovine peptic hemoglobin hydrolysate | |
Guillochon, Didier3  Zhao, Qiuyu3  Piot, Jean-Marie3  Ricart, Guy1  Thomas, Daniel2  | |
[1] Laboratoire de Spectrométrie de Masse, Lille I, 59655 Villeneuve d'Ascq Cédex, France;Laboratoire de Technologie Enzymatique, URA 1442 du CNRS, Université de Technologie de Compiègne, BP 649, Compiègne Cédex, France;Laboratoire de Technologie des Substances Naturelles, BP 179 — IUT A Lille I, 59653 Villeneuve d'Ascq Cédex, France | |
关键词: Bovine hemoglobin; Bradykinin potentiation; Peptic hydrolysate; High-performance liquid chromatography; Mass spectrometry; | |
DOI : 10.1016/0014-5793(92)80104-O | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
A bradykinin potentiating peptide was isolated from a peptic bovine hemoglobin hydrolysate, by the use of reversed-phase high-performance liquid chromatography (RP-HPLC). Its primary structure, determined by fast atom bombardment (FAB) and tandem mass spectrometry (MS/MS), was identical to fragment 129–134 of the α-chain of bovine hemoglobin. The bradykinin potency of this peptide, as exhibited by the guinea-pis ileum contraction, was significant and comparable with some others previously described.
【 授权许可】
Unknown
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