Autogenous translation regulation by Escherichia coli ATPase SecA may be mediated by an intrinsic RNA helicase activity of this protein

FEBS Letters

Gorbalenya, Alexander E.¹  Koonin, Eugene V.¹ 

[1] Institute of Microbiology, the Academy of Sciences, Prospekt Golec Oktyabrya 117811, Moscow and Institute of Pollomyelitis and Viral Encephalitides, the Academy of Medical Sciences, 142782, Moscow Region, Russia

关键词: Amino acid sequence comparison;    Conserved sequence motif;    Helicase;    Translation regulation;    Protein transport;    eIF-4A;    eukaryotic translation initiation factor 4A;   

DOI  :  10.1016/0014-5793(92)80009-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The seven conserved motifs typical of the helicase superfamily II have been identified in the sequences of Escherichia coli protein SecA, an ATPase mediating protein translocation across the inner membrane of the bacterium, and its Bacillus subtilis homolog Div. It is hypothesized that SecA and Div possess an RNA helicase activity and may couple ATP hydrolysis both to membrane translocation of proteins, and to hairpin unwinding in their own mRNAs, leading to the known autogenous regulation of translation.

【 授权许可】

Unknown