FEBS Letters | |
Induction of nitric oxide synthase by lipoteichoic acid from Staphylococcus aureus in vascular smooth muscle cells | |
Goulin-Schulz, Jocelyne1  Lonchampt, Marie-Odile1  Chabrier, Pierre Etienne1  Delaflotte, Sylvie1  Braquet, Pierre1  Auguet, Michel1  | |
[1] Institut Henri Beaufour, 1. avenue des Tropiques, 91952 Les Ulis Cedex, France | |
关键词: Lipoteichoic acid; Endotoxin; Nitric oxide (NO) synthase; Cyclic GMP; Rat aorta; | |
DOI : 10.1016/0014-5793(92)80356-L | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Inducible vascular nitric oxide synthase accounts for the contractile impairment observed in ondotoxemia. We provide evidence that lipoteichoic acid (LTA) from Staphylococcus aureus, a micro-organism without endotoxin, also induces nitric oxide synthase. Our study demonstrates that on endothelium-free rings of rat aorta. LTA-like lipopolysaccharide induces a loss of contractility restored by Methylene blue and N G-nitro-l-arginine-methyl ester (LNAME). Moreover in cultured vascular smooth muscle cells, LTA produces a dose-dependent increase in intracellular cyclic GMP which is antagonized by LNAME and prevented by dexamethasone.
【 授权许可】
Unknown
【 预 览 】
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