Induction of nitric oxide synthase by lipoteichoic acid from Staphylococcus aureus in vascular smooth muscle cells

FEBS Letters

Goulin-Schulz, Jocelyne¹  Lonchampt, Marie-Odile¹  Chabrier, Pierre Etienne¹  Delaflotte, Sylvie¹  Braquet, Pierre¹  Auguet, Michel¹ 

[1] Institut Henri Beaufour, 1. avenue des Tropiques, 91952 Les Ulis Cedex, France

关键词: Lipoteichoic acid;    Endotoxin;    Nitric oxide (NO) synthase;    Cyclic GMP;    Rat aorta;   

DOI  :  10.1016/0014-5793(92)80356-L

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Inducible vascular nitric oxide synthase accounts for the contractile impairment observed in ondotoxemia. We provide evidence that lipoteichoic acid (LTA) from Staphylococcus aureus, a micro-organism without endotoxin, also induces nitric oxide synthase. Our study demonstrates that on endothelium-free rings of rat aorta. LTA-like lipopolysaccharide induces a loss of contractility restored by Methylene blue and N ^G-nitro-l-arginine-methyl ester (LNAME). Moreover in cultured vascular smooth muscle cells, LTA produces a dose-dependent increase in intracellular cyclic GMP which is antagonized by LNAME and prevented by dexamethasone.

【 授权许可】

Unknown