An antipodean perception of the mode of action of glycoprotein hormones

FEBS Letters

Wiggins, Philippa¹  Renwick, Alistair² 

[1] Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand;Department of Biochemistry, University of Auckland, Private Bag 92019, Auckland, New Zealand

关键词: Glycoprotein hormone;    N-Glycan;    Structured water;   

DOI  :  10.1016/0014-5793(92)80314-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Continuance of vertebrate species and maintenance of metabolism have an absolute requirement for the glycoprotein hormones of the anterior pituitary gland. It is now firmly accepted that the N-glycans of these and the related placental hormone, chorionic gonadotropin, have essential if undefined roles in their mechanism of action. However, recent investigations by Weisshaar and his colleagues on the oligosaccharides of human luteinizing hormone and chorionic gonadotropin, do not support the generally accepted view of carbohydrates in hormone—receptor interactions and a further concept is proposed that invokes negative charges and changes in structured water.

【 授权许可】

Unknown