FEBS Letters | |
Time‐varying and static magnetic fields act in combination to alter calcium signal transduction in the lymphocyte | |
Yost, M.G.1  Liburdy, R.P.2  | |
[1] School of Public Health, University of California, Berkeley, CA 94720, USA;Bioelectromagnetics Research Facility, Research Medicine and Radiation Biophysics Division, Bldg. 74, Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA | |
关键词: Signal transduction; Calcium signalling; Electromagnetic field; Mitogen activation; Lymphocyte; | |
DOI : 10.1016/0014-5793(92)80361-J | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
We have tested the hypothesis that extremely low frequency (ELF) time-varying magnetic fields act in combination with static magnetic fields to alter calcium signalling in the lymphocyte. Results indicate that a 60-min exposure of thymic lymphocytes at 37 ± 0.05°C to a 16 Hz, 421 mG (42.1 μT) magnetic field simultaneously with a colinear static magnetic field of 234 mG (23.4 μT) (a.c./d.c. field intensity ratio = 1.8) inhibits calcium influx triggered by the mitogen Concanavalin A. Significantly, resting lymphocytes do not respond to the fields, thus, only mitogen-activated cells undergoing calcium signalling exhibit a field response. These results indicate that signal transduction involving calcium is an important biological constraint which operates to mediate this field interaction. Additional split field exposures show that the presence of the a.c. field or the d.c. field alone does not produce an effect. This is consistent with a proposed parametric resonance theory of interaction of low intensity magnetic fields with biological systems (L.L. Lednev (1991) Bioelectromagnetics 12, 71–75), which predicts the occurrance or biological effects at specific values for the frequency and field intensity of the ELF and static magnetic fields.
【 授权许可】
Unknown
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