Effect of glucagon on insulin receptor phosphorylation in intact liver cells

FEBS Letters

Tavaré, Jeremy M.¹  Young, Steven W.¹  Denton, Richard M.¹  Issad, Tarik¹ 

[1] Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK

关键词: Insulin receptor;    Liver;    Glucagon;    Insulin;    Phosphorylation;   

DOI  :  10.1016/0014-5793(92)80399-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Evidence is presented that incubation of rat liver cells with glucagon leads to an increase in the phosphorylation of specific serine residues within insulin receptors, particularly in the presence of insulin. However, no changes in either the tyrosine phosphorylation of the receptors or the tyrosine kinase activity towards a synthetic peptide substrate was detected.

【 授权许可】

Unknown