The control of cellular motility and the role of gelsolin

FEBS Letters

Magri, Ermes¹  Cataldi, Alberto¹  Grazi, Enrico¹  Cuneo, Paola¹ 

[1] Istituto di Chimica Biologica, Universitá di Ferrara, Via Borsari 46, 44100 Ferrara, Italy

关键词: Gelsolin;    Cell motility;   

DOI  :  10.1016/0014-5793(91)81409-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Solation of actin gel by gelsolin is much less efficient in the presence of a high concentration of macromolecular solutes. The rigidity of the gel formed by 12 μM actin is lowered from 4 to 0.33 dynes/cm² by 15 nM gelsolin, while in 6% (w/v) polyethylene glycol, rigidity is lowered only from 20 to 11 dynes/cm² by 64 nM gelsolin. Owing to the large concentration of protein, transitions in the fluid- and gel-like properties of the cytoplasm are expected to be problematic when promoted by gelsolin alone.

【 授权许可】

Unknown