Antiviral activity of some natural and synthetic sugar analogues

FEBS Letters

Schüller, Matthias²  Reutter, Werner¹  Huang, Richard¹  Lockhof, Oswald²  Dietsch, Ellen¹ 

[1] Institut für Molekularbiologie und Biochemie der Freien Universität Berlin, Arnimallee 22, D-1000 Berlin 33 (Dahlein), Germany;Bayer AG Wuppertal, D-5600 Wuppertal 1, Germany

关键词: Sugar analogue;    Synthetic sugar;    Antiviral activity;    Hemagglutinating titre;    Influenza virus;   

DOI  :  10.1016/0014-5793(91)81283-E

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A number of natural and synthetic sugar analogues have been tested for their antiviral activity, using an influenza virus strain as a model. Hemagglutinating titres (HA) and cytopathic effect (CPE) were surveyed to estimate the virus production. It was found that introduction of the benzyl group into these sugars generally causes them to become antivirally active. Substitution with methyl, acetyl, uridyl and thiocyanyl groups or derivatization with azido, isopropylidene and benzylidene groups were without effect. All sugars containing the 2-deoxy-2-acetamido group were inactive.

【 授权许可】

Unknown