8–37h‐CGRP antagonizes actions of amylin on carbohydrate metabolism in vitro and in vivo

FEBS Letters

Wang, Ming-Wei¹  Rink, Timothy J.¹  Cooper, Garth J.S.¹  Young, Andrew A.¹ 

[1] Physiology Department, Amylin Corporation, 9373 Towne Centre Drive, San Diego, California 92121, USA

关键词: Amylin;    Calcitonin gene-related peptide;    Rat soleus muscle;    Glucose;    Lactate;    Plasma calcium;   

DOI  :  10.1016/0014-5793(91)81282-D

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

^8–37hCGRP is a potent antagonist at calcitonin gene-related peptide (CGRP) liver membrane receptors; it also blocks vasodilator actions of CGRP and the related peptide, amylin, in intact rats. We now report that ^8–37hCGRP antagonizes amylin inhibition of insulin-stimulated labelled glucose uptake into isolated rat soleus muscle, and inhibits amylin-evoked elevation of plasma lactate and glucose in fasted anaesthetized rats. The different relative potencies of the 3 ligands (amylin, CGRP, ^8–37hCGRP) on the liver receptor and on the soleus muscle point to distinct CGRP receptors in liver membranes and amylin receptors on muscle cells.

【 授权许可】

Unknown