A novel P‐type ATPase from yeast involved in sodium transport

FEBS Letters

Rodriguez-Navarro, Alonso¹  Garciadeblas, Blanca¹  Haro, Rosario¹ 

[1] Departamento de Microbiologia, Escuela Técnica Superior de Ingenieros Agrónomos, E-28040 Madrid, Spain

关键词: Sodium pump;    Sodium ATPase;    Sodium efflux;    Lithium efflux;    Saccharomyces cerevisiae;   

DOI  :  10.1016/0014-5793(91)81280-L

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The gene ENA1 was cloned by its ability to complement the Li⁺ sensitivity of a low Li⁺-efflux strain. The nucleotide sequence of the cloned DNA fragment showed that there are two almost identical genes in tandem, and predicts that they encode P-ATPases. Disruption of both genes originated a strain defective in Na⁺ and Li⁺ effluxes, and sensitive to Na⁺, to Li⁺ and to alkaline pH. By transformation with ENA1 the defective effluxes and tolerances were repaired.

【 授权许可】

Unknown