Amylin injection causes elevated plasma lactate and glucose in the rat

FEBS Letters

Wang, Ming-Wei¹  Cooper, Garth J.S.¹  Young, Andrew A.¹ 

[1] Amylin Corporation, Department of Physiology, 9373 Towne Centre Drive, San Diego, CA 92121, USA

关键词: Gluconeogenesis;    Rat skeletal muscle;    Glycogen;    Glucose;    Lactate;    Blood pressure;   

DOI  :  10.1016/0014-5793(91)81113-M

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Intravenous injections of 25.5 nmol rat amylin into fasted anesthetized rats caused a rapid increase in plasma lactate followed by an increase in plasma glucose; there was a transient fall in blood pressure. Subcutaneous injection of 25.5 nmol amylin also caused increases in lactate and glucose but did not change blood pressure. Similar responses were observed during somatostatin infusion and in the absence of changes in catecholamines. These results fit with a scheme in which amylin elicits muscle glycogenolysis, release of lactate, and increased hepatic gluconeogenesis due to increased supply of substrate.

【 授权许可】

Unknown