Sphingosine and unsaturated fatty acids modulate the base exchange enzyme activities of rat brain membranes

FEBS Letters

McCartney, D.¹  Kanfer, J.N.¹ 

[1]Department of Biochemistry and Molecular Biology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada R3E 0W3

关键词: Sphingosine;    Arachadonic acid;    Oleic acid;    Serine base exchange enzymes;    Phosphatidylserine;    Base exchange enzymes;    Metabolic regulation;   

DOI  :  10.1016/0014-5793(91)81104-G

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The base exchange enzymes catalyze the incorporation of L-serine, ethanolamine and choline into their corresponding phospholipids. The L-serine base enzyme activity was increased 120% by 0.1 mM sphingosine. There was a modest increase of the ethanolamine base exchange enzyme activity but the choline base exchange enzyme activity was unaffected. Na-arachadonate, Na-oleate and Na-linolenate at 0.2 mM concentration increased the activity of the L-serine and ethanolamine base exchange enzymes but inhibited the choline base exchange enzyme activity. A model is proposed suggesting that modulations of the L-serine base exchange enzyme may participate in the regulation of the calcium phospholipid-dependent protein kinase C.

【 授权许可】

Unknown