Cloning and sequence analysis of pituitary cDNA encoding the β‐subunit of Xenopus proteasome

FEBS Letters

Martens, Gerard J.M.¹  van Riel, Maarten C.H.M.¹ 

[1]Department of Animal Physiology, University of Nijmegen, Toernooiveld, 6525 ED Nijmegen, The Netherlands

关键词: Proteasome;    Multicatalytic proteinase;    β-Subunit;    cDNA sequence;    Xenopus pituitary;   

DOI  :  10.1016/0014-5793(91)81098-S

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The proteasome is a multicatalytic proteinase composed of a number of non-identical subunits. A Xenopus pituitary cDNA was isolated and found to code for the β-subunit of proteasome. The amino acid sequence deduced from the open reading frame consisted of 215 amino acid residues with a calculated molecular weight of 23 979. A comparative structural analysis indicated that the proteasome subunits can be divided into two groups with the same evolutionary origin. One group consists of subunits with an N-terminally blocked residue and includes components C2, C3, C8 and C9, while the second group of non-blocked proteins includes components C5 and the β-subunit.

【 授权许可】

Unknown