Laminin A‐related domains in crb protein of Drosophila and their possible role in epithelial polarization

FEBS Letters

Patthy, László¹ 

[1] Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, P.O. Box 7, H-1518, Hungary

关键词: Laminin: Epithelial polarization: Protein evolution;   

DOI  :  10.1016/0014-5793(91)80917-R

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It is shown that four domains of the integral membrane protein crb of Drosophila are homologous with five C-terminal domains of the laminin A chain and merosin. Since the latter domains of laminin A have been implicated in determining epithelial polarity, the homology may suggest a similar function for these domains or crb. Such a function would be consistent with the known importance of crb for organization of epithelia in Drosophila.

【 授权许可】

Unknown