Protein kinase C activity in rat skeletal muscle Apparent relation to body weight and muscle growth

FEBS Letters

Richter, Erik A.¹  Nielsen, Niss B.S.¹ 

[1] August Krogh Institute, University of Copenhagen, Copenhagen, Denmark

关键词: Compensatory hypertrophy;    Aping;    Growth;   

DOI  :  10.1016/0014-5793(91)80913-N

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Protein kinase C (PKC) may be involved in growth regulation. In the present study the relationship between body weight, and thereby age, and the activity of PKC in muscle as well as in rapidly growing overloaded muscle were investigated. PKC activity in music was linearly inversely correlated to rat weight in both soleus (r = −0.59, P < 0.05) and in plantaris (r = −0.74, P < 0.01) muscles. During compensatory hypertrophy. PKC activity per muscle was maximally increased compared with the contralateral control muscles after 4days in both soleus(126%)and in plantaris (105%) but had returned to basal levels by the 9th day. The data are in agreement with a role for PKC in muscle growth.

【 授权许可】

Unknown