Endothelium‐derived relaxing factor is a nitrosyl iron complex with thiol ligands

FEBS Letters

Vanin, Anatoly F.¹ 

[1] Institute of Chemical Physics, Academy of Sciences of USSR, Kosygin Str. 4, 117334 Moscow, USSR

关键词: Endothelium-derived relaxing factor;    Nitric oxide: Nitrosyl non-heme iron complex;    Free iron;    DNIC;    dinitrosyl iron complex;    DETC;    dicethyldithiocarbamate anion;    EDRF;    endothelium-derived relaxing factor;    ESR;    electron spin resonance;    MNIC;    mononitrosyl iron complex;    NO;    nitric oxide;   

DOI  :  10.1016/0014-5793(91)80894-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A hypothesis is put forward on the nature of the endothelium-derived relaxing factor (EDRF) which is released from vascular endothelial cells by acetylcholine, bradykinin and other agonists. It is suggested that EDRF is a nitrosyl iron complex with low-molecular thiol ligands, most probably with cysteine. Its active principle is nitric oxide (NO). This free radical is stabilized by inclusion into the iron complex, which promotes NO transfer within the cell and between cells. Subsequent release of NO from these complexes results from thiol group oxidation.

【 授权许可】

Unknown