Inhibition of aspartic proteinases by propart peptides of human procathepsin D and chicken pepsinogen

FEBS Letters

Fusek, M.¹  Voburka, Z.¹  Baudyš, M.¹  Mareš, M.¹  Vágner, J.² 

[1] Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Prague, Czechoslovakia;Research Institute for Feed Supplements and Veterinary Drugs, Jilové, Prague, Czechoslovakia

关键词: Aspartic proteinase;    Propart peptide;    Human procathepsin D;    Chicken pepsinogen: Inhibition;    Zymogen activation;    CPP;    chicken propart peptide;    HCDP;    human cathepsin D propart peptide;    Tris;    tris-(hydroxymethyl)aminomethane;    F-(NO2);    p-nitrophenylalanyl;    PDI;    potato tubers cathepsin D inhibitor;   

DOI  :  10.1016/0014-5793(91)80040-A

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two propart peptides of aspartic proteinases. the propart peptide of chicken pepsin and human cathepsin D, respectively, were investigated from the point of view of their inhibitory activity for a set of aspartic proteinases. These peptides display a very broad inhibitory spectrum. The strongest inhibition was observed for pepsin A-like proteinases where propart peptides can be used as titrants of active enzymes.

【 授权许可】

Unknown