Evidence that reverse cholesterol transport is stimulated by lipolysis of triglyceride‐rich lipoproteins

FEBS Letters

Nanjee, M.N.¹  Miller, N.E.¹ 

[1]Section on Endocrinology and Metabolism, Department of Medicine, Bowman Gray School of Medicine, Winston-Salem, USA

关键词: Cholesterol;    Triglyceride;    High density lipoprotein;    Heparin;    Lipoprotein lipase;    Rabbit;   

DOI  :  10.1016/0014-5793(91)80742-L

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The hypothesis that reverse cholesterol transport by high density lipoprotein (HDL) is augmented by lipolysis of triglyceride-rich lipoproteins received support from experiments in rabbits whose tissue cholesterol had been pre-labeled with [³H]cholesterol several weeks earlier. When lipolysis was stimulated by intravenous heparin (which releases lipoprotein lipase from vascular endothelium), reciprocal changes in plasma triglyceride and HDL cholesterol concentrations were accompanied by a rise in the specific radioactivity of HDL cholesterol, indicative of increased transfer of cholesterol into HDL from slowly exchanging cholesterol pools in extra-hepatic tissues.

【 授权许可】

Unknown