Hormone specific regulation of natural killer cells by cortisol Direct inactivation of the cytotoxic function of cloned human NK cells without an effect on cellular proliferation

FEBS Letters

Callewaert, Denis M.²  Moudgil, Virinder K.¹  Waite, Ross²  Radcliff, Gilbert² 

[1] Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA;Department of Chemistry, Oakland University, Rochester, MI 48309, USA

关键词: NK cell;    Immunoregulation;    Cellular cytotoxicity;    Cortisol;    Corticosteroid;   

DOI  :  10.1016/0014-5793(91)80736-M

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Corticosteroids have previously been reported to partially inhibit the natural cytotoxic activity of peripheral blood lymphocytes. However, since only a few percent of peripheral lymphocytes are natural killer (NK) cells, it has not been possible to determine whether corticosteroids directly inhibit NK cells or mediate this effect via other cell types. This report documents direct functional inactivation, but unimpeded proliferation, of cloned human NK cells by subphysiologic levels of cortisol. In contrast, high concentrations of testosterone, progesterone or estradiol had no significant effect on proliferation or cytotoxic activity of the cloned NK cells. The kinetics of inhibition of NK function by cortisol are consistent with a transcription-dependent mechanism.

【 授权许可】

Unknown