Selective effect of inhibitors on inner mitochondrial membrane channels

FEBS Letters

Antonenko, Yuri N.¹  Tedeschi, Henry²  Kinnally, Kathleen W.²  Perini, Sean² 

[1] Department of Bioenergetics, A.N. Belozersky Laboratory, Moscow State University, USSR;Department of Biological Science, State University of New York at Albany, USA

关键词: Mitochondrial channel;    Patch-clamp;    Pharmacology;    Mitochondrial channel;    Inner mitochondrial membrane;   

DOI  :  10.1016/0014-5793(91)80731-H

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of amphiphilic cationic drugs on the channel activity of the mitochondrial inner membrane was examined with patch-clamp techniques. The therapeutic drugs amiodarone, propranolol and quinine reduced the probability of being open for the multiconductance channel (MCC) activity (levels from 30 pS to over I nS). While amiodarone decreased the probability of being open for the voltage dependent ∼ 100 pS channel, it increased the conductance 42 ± 20% (mean ± SD, n = 6) with no significant change in mean open time. Similar results were obtained with propranolol. These data indicate that the ∼ 100 pS channel is distinct from MCC activity.

【 授权许可】

Unknown