Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin‐11

FEBS Letters

Mita-Honjo, Katsuko¹  Takiguchi, Yo¹  Sakakibara, Sachiko¹  Ohsumi, Jun¹  Shimoda-Takano, Kumi¹  Kawashima, Ichiro¹  Ishikawa, Hiroko¹  Miyadai, Kenji¹ 

[1]Bioscience Research Laboratories, Sankyo Co. Ltd., 2-58, Hiromachi 1-chome, Shinagawa-ku, Tokyo 140, Japan

关键词: Adipogenesis inhibitory factor;    Interleukin-II;    cDNA cloning;    Bone marrow stromal cell;   

DOI  :  10.1016/0014-5793(91)80587-S

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A cDNA encoding a novel adipogenesis inhibitory factor (AGIF) that inhibits the process of adipogenesis in mouse 3T3-L1 preadipocytes was cloned from a cDNA library of the human bone marrow-derived stromal cell line KM-102. The cloned cDNA contains an open reading frame coding for an AGIF precursor of 199 amino acids. Analysis of the sequence of this cDNA revealed identity of this factor with a recently reported novel cytokine, designated interleukin-11 (IL-11). AGIF/IL-11 may play an important role in stromal cell-associated hematopoiesis through its regulatory action on adipocyte differentiation in the bone marrow microenvironment.

【 授权许可】

Unknown