Inhibition of electrical activity in mouse pancreatic β‐cells by the ATP/ADP translocase inhibitor, bongkrekic acid

FEBS Letters

Bangham, J.A.³  Smith, P.A.¹  Kiranadi, B.² 

[1] University Laboratory of Physiology, Parks Road, Oxford, OX1 3PT, UK;Bogor Agriculture University-School of Veterinary Medicine, Bogor 16151, Indonesia;School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK

关键词: Bongkrekic acid;    Metabolism;    ATP-sensitive potassium channel;    Pancreatic β-cell;   

DOI  :  10.1016/0014-5793(91)80561-G

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Bongkrekic acid causes fatal food poisoning which is associated with hyperglycaemia. Here we demonstrate that bongkrekic acid, a potent inhibitor of the mitochondrial ATP/ADP translocase, inhibits glucose-induced electrical activity in the pancreatic β-cell through the simulation of ATP-sensitive potassium channel (K-ATP-channel) activity. By comparison of its effects with those of oligomycin, we suggest that bongkrekic acid acts by the inhibition of glucose metabolism and may induce hyperglycaemia by impairing β-cel function.

【 授权许可】

Unknown