Aminoacyl‐tRNA synthetases and DNA replication Molecular mimicry between RNAII and tRNALys

FEBS Letters

Mirande, Marc¹ 

[1] Laboratoire d'Enzymologie, Centre National de la Recherche Scientifique, 91190 Gif-sur-Yvette, France

关键词: Lysyl-tRNA synthetase;    ColE1 replicon;    tRNA identity;    Molecular mimicry;   

DOI  :  10.1016/0014-5793(91)80539-F

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Recent data pertaining to different research areas, aminoacyl-tRNA synthetases and replication of ColE1 plasmids, have provided mutually attractive prospects. The gene encoding Escherichia coli lysyl-tRNA synthetase was first isolated as a host suppressor mutation that restores replication of a mutant ColE1 replicon. Comparison of RNAII and tRNA^Lys suggests that lysyl-tRNA synthetase is involved in the formation of the displacement loop required for ColE1 plasmids replication and provides major identity elements of tRNA^Lys.

【 授权许可】

Unknown