The transcriptional control proteins c‐Myb and v‐Myb contain a basic region DNA binding motif

FEBS Letters

Carr, Mark D.²  Mott, Richard F.¹ 

[1] Laboratory of Mathematical Biology, National Institute of Medical Research, The Ridgeway, Mill Hill, London, UK;Laboratory of Molecular Structure, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK

关键词: Myb: Basic region DNA binding motif;   

DOI  :  10.1016/0014-5793(91)80498-R

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A class of transcriptional control proteins, typified by c-Myb, are characterised by a highly conserved N-terminal DNA binding domain, which is composed of either 2 or 3 imperfect repeats of about 52 amino acids. A sequence homology search of the SWISSPROT protein sequence data bank with this region from mouse c-Myb has allowed us to identify an area near the C-terminus of repeat 2 that contains a short sequence motif, known as the basic region, which forms the DNA binding site in both leucine zipper and helix-loop-helix transcription factors. We therefore propose that this region of repeat 2 and the homologous part of repeat 3 will form the Myb DNA binding site.

【 授权许可】

Unknown