Altered glucose 1,6‐bisphosphate and fructose 2,6‐biphosphate levels in low‐frequency stimulated rabbit fast‐twitch muscle

FEBS Letters

Cadefau, Juan¹  Green, Howard J.¹  Pette, Dirk¹ 

[1] Fakultät für Biologie, Universität Konstanz, Postfact 5560, D-7750 Konstanz, Germany

关键词: Chronic low-frequency stimulation;    Rabbit fast-twitch muscle;    Glucose 1;    6-bisphosphate;    Fructose 2;    6-bisphosphate;   

DOI  :  10.1016/0014-5793(91)80455-C

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Glucose 1,6-bisphosphate (Glc-1,6-P₂) and fructose 2,6-bisphospate (Fru-2,6-P₂) concentration display pronounced increases in rabbit fast-twitch muscle during chronic low-frequency stimulation. These increases are first seen after stimulation periods exceeding 3 h and reach maxima after 12–24h of stimulation (approximately 3-fold for Glc-1,6-P₂ and 5-fold for Fru-2,6-P₂). Both matabolites regress to normal values after stimulation periods longer than 4 days. The fact that their increases coincide with the replenishment of glycogen after its initial depletion, could point to a role of Glc-1,6-P₂ and Fru-2,6-P2 in glycogen metabolism.

【 授权许可】

Unknown